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Michaels have double sided magnets3/20/2023 ![]() MDMA is also a substrate for monoamine oxidase ( 11) and has been shown to directly interact with 5HT receptors ( 12). MDMA is a ring-substituted amphetamine that acutely raises extracellular levels of serotonin (5HT), and to a lesser extent dopamine, and norepinephrine (NE) by reversing the serotonin transporter (SERT), dopamine transporter, NE transporter, or vesicular monoamine transporters ( 8– 10). ![]() In reality MDMA and related amphetamines produce profound acute effects on cardiovascular physiology that may lead to cardiotoxicity and increased susceptibility for heart-related fatalities, in addition to producing neurocognitive and neurobehavioral deficits. ) that MDMA is a relatively benign drug with mystical, empathogenic properties contribute to the problem. The perception by the general public and advocacy groups (e.g. Despite research elucidating the mechanism by which MDMA negatively affects central and peripheral physiology, MDMA is still used in alarming quantities by teenagers and adults ( 6, 7). In fact, numerous studies show that MDMA increases heart rate and blood pressure in rats ( 1, 2) as well as humans ( 3– 5). ![]() euphoria, intense empathy for others, and extreme relaxation) coincide with numerous negative effects such as tachycardia, hypertension, and indirect cardiac stressors associated with suppression of appetite, thirst, and sleep. MDMA abuse remains a societal problem in developed nations despite two decades of research indicating that the acute positive effects of MDMA (e.g. The contributions of serotonergic signaling on MDMA-induced changes in cardiac metabolism remain to be determined.ģ,4-Methylenedioxymethamphetamine (MDMA ecstasy) is a recreational drug that has stimulant and hallucinogen-like properties. The results are consistent with the notion that MDMA has significant effects on cardiovascular serotonergic tone and disrupts the metabolic homeostasis of energy regulation in cardiac tissue, potentially increasing utilization of fatty acid metabolism. Finally, choline levels were significantly decreased by MDMA in heart. MDMA significantly altered the MR-visible profile with an increase in carnitine and no change in other key compounds involved in cardiomyocyte energy metabolomics. Serotonin, but not NE, levels were significantly and dose-dependently decreased by MDMA in the heart wall. MDMA significantly and dose-dependently increased body temperature, a hallmark of amphetamines. Body temperature was measured following each MDMA administration and serotonin and norepinephrine (NE) levels were measured by high pressure liquid chromatography (HPLC) in heart tissue from treated animals. MDMA effects on MR-visible choline, glutamate, glutamine, and taurine were also determined. High resolution magic angle spinning proton magnetic resonance spectroscopy ( 1H-MRS) at 11.7 T, a specialized version of MRS aptly suited for analysis of semi-solid materials such as intact tissue samples, was used to measure the cardiac metabolomic profile, including alanine, lactate, succinate, creatine, and carnitine, in heart tissue from rats treated with MDMA. To determine the effects of MDMA on cardiac metabolites in rats, MDMA (0, 5, or 10 mg/kg) was injected every 2 h for a total of four injections animals were sacrificed 2 h after the last injection (8 h drug exposure), and their hearts removed and tissue samples from left ventricular wall dissected. Acute exposure to MDMA has profound cardiovascular effects on blood pressure and heart rate in humans and animals. Place a picture or video of your version of magnetic putty in the comments below.Despite the potential for deleterious (even fatal) effects on cardiac physiology, 3,4-methylenedioxymethamphetamine (MDMA ecstasy) abuse abounds driven mainly by its euphoric effects. ![]() What are you waiting for? Get going and make your own magnetic putty! ![]() If all else fails, take the fabric to the dry cleaners and tell them it's a silicone-based stain. Alternatively you can apply rubbing alcohol to area and work out the putty, try a concealed test-area first. If you get magnetic putty stuck to fabric you can try placing the magnet on top of the fabric and the putty may work it's way out (wait 24 hours). Use caution when playing with your magnetic putty. Of course, aside from being magnetic your putty still retains all the properties of the original Silly Putty.Ĭaution: Putty has been known to leave a residue on some surfaces, even more so with the iron oxide powder. Some frames have been sped-up to illustrate magnetic properties. There's plenty of fun to be had, check out the video I made with some of the fun you can do. You can stretch out a strand and make it follow your magnet, you can polarize your putty to work as a magnet itself, and then there's the classic of placing the magnet directly on the putty and watching it envelop the magnet. That's it, you're done! Grab your magnet and start experimenting with your new magnetic putty. ![]()
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